GSK3-Mediated BCL-3 Phosphorylation Modulates Its Degradation and Its Oncogenicity
نویسندگان
چکیده
منابع مشابه
GSK3-mediated BCL-3 phosphorylation modulates its degradation and its oncogenicity.
The oncoprotein BCL-3 is a nuclear transcription factor that activates NF-kappaB target genes through formation of heterocomplexes with p50 or p52. BCL-3 is phosphorylated in vivo, but specific BCL-3 kinases have not been identified so far. In this report, we show that BCL-3 is a substrate for the protein kinase GSK3 and that GSK3-mediated BCL-3 phosphorylation, which is inhibited by Akt activa...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2004
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2004.09.004